Journal article
Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis
A Elhakeem, AE Taylor, HM Inskip, JY Huang, T Mansell, C Rodrigues, F Asta, SM Blaauwendraad, SE Håberg, J Halliday, MW Harskamp-Van Ginkel, JR He, VWV Jaddoe, S Lewis, GM Maher, Y Manios, FP McCarthy, IKM Reiss, F Rusconi, T Salika Show all
European Heart Journal | OXFORD UNIV PRESS | Published : 2023
Abstract
Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age Methods Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance and results markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included i..
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Awarded by NIHR Bristol Biomedical Research Centre
Funding Acknowledgements
Acknowledgements We thank all cohort members and researchers who participated in the study. Cohort-specific acknowledgments can be found in Supplementary material online, Text S2. Data used in this study are available to bone fide researchers upon request to each cohort. Details of how to access the data are provided in Supplementary material online, Text S2. Please contact Professor Deborah Lawlor (d.a.lawlor@bristol.ac.uk) and Dr Ahmed Elhakeem (a.elhakeem@bristol.ac.uk) if you have relevant data and would like to join the ART-Health Cohort Collaboration and contribute to future collaborations.