Postnatal corticosteroids and developmental outcomes in extremely preterm or extremely low birth weight infants: The Victorian Infant Collaborative Study 2016–17 cohort

E Douglas; KA Hodgson; JE Olsen; BJ Manley; CT Roberts; E Josev; PJ Anderson; LW Doyle; PG Davis; JLY Cheong; R Boland; A Burnett; M Charlton; M Clark; N Davis; J Duff; L Hickey; E Johnston; K Lee; R Mainzer; M McDonald; B Novella; G Opie; L Pigdon; G Roberts; K Scott; A Spittle; P Stevens; A Stewart; AM Turner; T Woods

Journal article

Postnatal corticosteroids and developmental outcomes in extremely preterm or extremely low birth weight infants: The Victorian Infant Collaborative Study 2016–17 cohort

E Douglas, KA Hodgson, JE Olsen, BJ Manley, CT Roberts, E Josev, PJ Anderson, LW Doyle, PG Davis, JLY Cheong, R Boland, A Burnett, M Charlton, M Clark, N Davis, J Duff, L Hickey, E Johnston, K Lee, R Mainzer Show all

Acta Paediatrica International Journal of Paediatrics | WILEY | Published : 2023

DOI: 10.1111/apa.16696

Abstract

Aim: Systemic postnatal corticosteroids are used to treat or prevent bronchopulmonary dysplasia (BPD) in extremely preterm (EP) or extremely low birth weight (ELBW) infants but are associated with long-term harm. We aimed to assess the relationship between cumulative postnatal corticosteroid dose and neurodevelopmental outcomes. Methods: Longitudinal cohort study of all EP/ELBW livebirths in Victoria, Australia 2016–2017. Perinatal data were collected prospectively. Neurodevelopmental assessment was performed at 2 years' corrected age. Linear and logistic regression were used to determine relationships between cumulative corticosteroid dose and neurodevelopment, adjusted for gestational age,..

View full abstract

University of Melbourne Researchers

Brett J. Manley Author

Lex Doyle Author

Peter Davis Author

Jeanie Cheong Author

Related Projects (1)

GENERATING AND APPLYING CLINICAL RESEARCH TO IMPROVE THE OUTCOMES OF NEONATAL INTENSIVE CARE

The transition to independent breathing in the minutes after birth is challenging for many babies, particularly those born preterm. I am per..

Grants

Awarded by Murdoch Children's Research Institute

Funding Acknowledgements

National Health and Medical Research Council of Australia, Grant/Award Number: 1157782; Emerging Leadership Fellowship, Grant/Award Number: 1175634; the Medical Research Future Fund of Australia, Grant/Award Number: