Higher consumption of ultra-processed foods and increased likelihood of central nervous system demyelination in a case-control study of Australian adults

A Mannino; A Daly; E Dunlop; Y Probst; AL Ponsonby; IAF van der Mei; C Chapman; A Coulthard; K Dear; T Dwyer; T Kilpatrick; R Lucas; T McMichael; B Taylor; P Valery; D Williams; LJ Black

Journal article

Higher consumption of ultra-processed foods and increased likelihood of central nervous system demyelination in a case-control study of Australian adults

A Mannino, A Daly, E Dunlop, Y Probst, AL Ponsonby, IAF van der Mei, C Chapman, A Coulthard, K Dear, T Dwyer, T Kilpatrick, R Lucas, T McMichael, B Taylor, P Valery, D Williams, LJ Black

European Journal of Clinical Nutrition | Springer Nature [academic journals on nature.com] | Published : 2023

DOI: 10.1038/s41430-023-01271-1

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Abstract

Background: Consumption of ultra-processed foods (UPFs) has been linked to risk of chronic diseases, with scant evidence in relation to multiple sclerosis (MS). Methods: We tested associations between UPF consumption and likelihood of a first clinical diagnosis of central nervous system demyelination (FCD) (267 cases, 508 controls), a common precursor to MS. We used data from the 2003–2006 Ausimmune Study and logistic regression with full propensity score matching for age, sex, region of residence, education, smoking history, body mass index, physical activity, history of infectious mononucleosis, dietary misreporting, and total energy intake. Results: Higher UPF consumption was statisti..

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University of Melbourne Researchers

Anne-Louise Ponsonby Author

Trevor Kilpatrick Author

Grants

Awarded by National Multiple Sclerosis Society

Funding Acknowledgements

Funding for the Ausimmune Study was provided by the National Multiple Sclerosis Society of the United States of America (NMSS RG 3364A1/2), the National Health and Medical Research Council of Australia (313901) and Multiple Sclerosis Research Australia. LJB is supported by Multiple Sclerosis Western Australia (MSWA), a Multiple Sclerosis Australia Postdoctoral Fellowship and a Curtin University Research Fellowship. AM was supported by an MSWA Summer Scholarship. AD is supported by MSWA. ALP is supported by National Health and Medical Research Council of Australia Senior Research Fellowships. Funding bodies had no role in the design or conduct of the study; collection, management, analysis or interpretation of data; or preparation, review or approval of the manuscript