Journal article
A data-driven transdiagnostic analysis of white matter integrity in young adults with major psychiatric disorders
DF Hermens, SN Hatton, D White, RSC Lee, AJ Guastella, EM Scott, SL Naismith, IB Hickie, J Lagopoulos
Progress in Neuro Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Abstract
Diffusion tensor imaging (DTI) has been utilized to index white matter (WM) integrity in the major psychiatric disorders. However, the findings within and across such disorders have been mixed. Given this, transdiagnostic sampling with data-driven statistical approaches may lead to new and better insights about the clinical and functional factors associated with WM abnormalities. Thus, we undertook a cross-sectional DTI study of 401 young adult (18–30 years old) outpatients with a major psychiatric (depressive, bipolar, psychotic, or anxiety) disorder and 61 healthy controls. Participants also completed self-report questionnaires and underwent neuropsychological assessment. Fractional anisot..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors declare that there are no competing financial interests in relation to the work described. Potential conflicts of interest may arise from the following: DFH has received honoraria for educational seminars (about ADHD) from Janssen-Cilag and Eli Lilly. SLN has received honoraria for an educational seminar for Lundbeck (cognition in depression). IBH has led a range of community-based and pharmaceutical industry-supported depression awareness and education and training programs. He has led depression and other mental health research service evaluation or investigator-initiated research projects that have been supported by a variety of pharmaceutical partners. Servier and Pfizer support current investigator-initiated studies. He has received honoraria for his contributions to professional educational seminars related to depression, youth mental health and circadianrhythms research. He has received travel support from Servier to attend scientific meetings related specifically to circadian-rhythm disorders. The authors report no other biomedical financial interests or potential conflicts of interest.