Journal article
Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder
J Mundy, C Hübel, J Gelernter, D Levey, RM Murray, M Skelton, MB Stein, E Vassos, G Breen, JRI Coleman, AX Maihofer, CM Nievergelt, DG Baker, VB Risborough, JR Calabrese, S Galea, DJ Stein, N Koen, S Dalvie, AE Aiello Show all
Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2022
Abstract
Background. Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly reported co-occurring mental health consequences of psychological trauma exposure. The disorders have high genetic overlap. Trauma is a complex phenotype but research suggests that trauma sensitivity has a heritable basis. We investigated whether sensitivity to trauma in those with MDD reflects a similar genetic component in those with PTSD. Methods. Genetic correlations between PTSD and MDD in individuals reporting trauma and MDD in individuals not reporting trauma were estimated, as well as with recurrent MDD and single-episode MDD, using genome-wide association study (GWAS) summary statistics..
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Awarded by National Institute for Health and Care Research
Funding Acknowledgements
This study represents independent research funded partly by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London and partly by the Lord Leverhulme Charitable Grant (Professor Robin M. Murray). High-performance computing facilities were funded with capital equipment grants from the Guy's & St. Thomas' Charity (TR 130505) and Maudsley Charity (award 980).