Journal article
Tenecteplase Treatment And Thrombus Characteristics Associated With Early Reperfusion - An EXTEND-IA TNK Trials Analysis
Vignan Yogendrakumar, Leonid Churilov, Prodipta Guha, James Beharry, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Helen Brown, Helen M Dewey, Tissa H Wijeratne, Bernard Yan, Gagan Sharma, Patricia Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen Davis, Bruce Campbell
STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2023
Abstract
Background: Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that influence alteplase-associated reperfusion. In this study, we assessed the reperfusion efficacy of tenecteplase and alteplase in subgroups based on these characteristics in a pooled analysis of the EXTEND-IA TNK trials. Methods: Patients with large vessel occlusion (LVO) were randomized to treatment with tenecteplase (0.25mg/kg or 0.4mg/kg) or alteplase (0.9mg/kg) prior to thrombectomy. The primary outcome, early reperfusion, was defined as the absence of retrievable thrombus or >50% reperfusion on initial angiographic ass..
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