Journal article
In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance
L Kedzierski, A Er Qi Tan, I Jia Hui Foo, D Narayanan, N Moily, HA McQuilten, SE Nicholson, JK Fazakerley
Immunology and Cell Biology | Published : 2023
DOI: 10.1111/imcb.12625
Abstract
Central nervous system virus infections are a major cause of morbidity and mortality worldwide and a significant global public health concern. As in many tissues, inflammation and immune responses in the brain, despite their protective roles, can also be harmful. Control of brain inflammation is important in many neurological diseases from encephalitis to multiple sclerosis and neurogenerative disease. The suppressors of cytokine signaling (SOCS) proteins are a key mechanism controlling inflammatory and immune responses across all tissues including the brain. Using a mouse model system, we demonstrate that lack of SOCS4 results in changes in the pathogenesis and clinical outcome of a neurotr..
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Funding Acknowledgements
We acknowledge the Melbourne Cytometry Platform (TheDoherty Institute) for provision of flow cytometry services and the Phenomics Australia Histopathology and Digital Slide Service at the University of Melbourne for support with the histopathological assessments. We thank Melbourne Bioresources Platform staff at the Doherty Institute. The workwas funded by a University of Melbourne grant to JKF. IJHFis a recipient of Melbourne Research Scholarship. DN was arecipient of Melbourne International Fee Remission Scholarship and Melbourne International Research Scholarship. Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians