Journal article
Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis
NA Fithri, Y Wu, G Cowin, F Akhter, HDN Tran, B Tse, NW van Holthe, SS Moonshi, K Peter, X Wang, NP Truong, HT Ta
Applied Materials Today | Published : 2023
Abstract
Thrombosis is a major concern worldwide as thrombosis-related deaths are attributed to one in five deaths globally. Establishing a clot-targeting theranostic particle for diagnosis and treatment of thrombosis related diseases is crucial to provide rapid life-saving intervention. Herein, we developed activated platelet targeted gold-iron oxide nanoparticles (AuIONP) as a robust and powerful probe facilitating triple imaging modalities, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and fluorescence imaging (FLI). Additionally, the antibody tagged AuIONP was utilised to facilitate photothermal thrombolysis, stimulated by the exposure to near-infrared (NIR) laser at 80..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
N.A.F. acknowledges the financial support in the form of PhD scholarship funded by Australia Awards Program. H.T.T and N.P.T. acknowledge the funding support of an Ideas grant (APP2002827) from the National Health and Medical Research Council. H.T.T is supported by a Heart Foundation Future Leader Fellowship (102761) and NHMRC grants (APP1037310, APP1182347) . N.P.T. is grateful for the award of a DECRA Fellowship (DE180100076) and a Discovery Project grant (DP200100231) from the Australian Research Council. K.P is supported by an NHMRC Investigator Fellowship. X.W is supported by a National Heart Foundation Future Leader Fellowship and a Baker Fellowship.