Mid-treatment adaptive planning during thoracic radiation using 68 Ventilation-Perfusion Positron emission tomography

N Bucknell; N Hardcastle; R Gunewardena; L Nguyen; J Callahan; D Ball; L Selbie; T Kron; GA Turgeon; MS Hofman; S Siva

Journal article

Mid-treatment adaptive planning during thoracic radiation using 68 Ventilation-Perfusion Positron emission tomography

N Bucknell, N Hardcastle, R Gunewardena, L Nguyen, J Callahan, D Ball, L Selbie, T Kron, GA Turgeon, MS Hofman, S Siva

Clinical and Translational Radiation Oncology | ELSEVIER IRELAND LTD | Published : 2023

DOI: 10.1016/j.ctro.2023.100599

Abstract

Four-Dimensional Gallium 68 Ventilation-Perfusion Positron Emission Tomography (68Ga-4D-V/Q PET/CT) allows for dynamic imaging of lung function. To date there has been no assessment of the feasibility of adapting radiation therapy plans to changes in lung function imaged at mid-treatment function using 68Ga-4D-V/Q PET/CT. This study assessed the potential reductions of dose to the functional lung when radiation therapy plans were adapted to avoid functional lung at the mid-treatment timepoint using volumetric arc radiotherapy (VMAT). Methods: A prospective clinical trial (U1111-1138–4421) was performed in patients undergoing conventionally fractionated radiation therapy for non-small cell lu..

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University of Melbourne Researchers

Nicholas Hardcastle Author

David Ball Author

Tomas Kron Author

Michael Hofman Author

Grants

Funding Acknowledgements

Nicholas Bucknell is supported by the RANZCR Windeyer Fellowship and an Australian Commonwealth government Research Training Program Scholarship Shankar Siva is supported by the Cancer Council Victoria Colebatch Fellowship Michael Hofman is supported by a Peter MacCallum Foundation Research Leadership Grant.