Comparative effectiveness in multiple sclerosis: A methodological comparison

I Roos; I Diouf; S Sharmin; D Horakova; EK Havrdova; F Patti; V Shaygannejad; S Ozakbas; G Izquierdo; S Eichau; M Onofrj; A Lugaresi; R Alroughani; A Prat; M Girard; P Duquette; M Terzi; C Boz; F Grand’Maison; P Sola; D Ferraro; P Grammond; R Turkoglu; K Buzzard; O Skibina; B Yamou; A Altintas; O Gerlach; V van Pesch; Y Blanco; D Maimone; J Lechner-Scott; R Bergamaschi; R Karabudak; C McGuigan; E Cartechini; M Barnett; S Hughes; MJ Sa; C Solaro; C Ramo-Tello; S Hodgkinson; D Spitaleri; A Soysal; T Petersen; F Granella; K de Gans; P McCombe; R Ampapa; B Van Wijmeersch; A van der Walt; H Butzkueven; J Prevost; JL Sanchez-Menoyo; G Laureys; R Gouider; T Castillo-Triviño; O Gray; E Aguera-Morales; A Al-Asmi; C Shaw; N Deri; T Al-Harbi; Y Fragoso; T Csepany; AP Sempere; I Trevino-Frenk; J Schepel; F Moore; C Malpas; T Kalincik

Journal article

Comparative effectiveness in multiple sclerosis: A methodological comparison

I Roos, I Diouf, S Sharmin, D Horakova, EK Havrdova, F Patti, V Shaygannejad, S Ozakbas, G Izquierdo, S Eichau, M Onofrj, A Lugaresi, R Alroughani, A Prat, M Girard, P Duquette, M Terzi, C Boz, F Grand’Maison, P Sola Show all

Multiple Sclerosis Journal | Published : 2023

DOI: 10.1177/13524585231151394

Download PDF

Abstract

Background: In the absence of evidence from randomised controlled trials, observational data can be used to emulate clinical trials and guide clinical decisions. Observational studies are, however, susceptible to confounding and bias. Among the used techniques to reduce indication bias are propensity score matching and marginal structural models. Objective: To use the comparative effectiveness of fingolimod vs natalizumab to compare the results obtained with propensity score matching and marginal structural models. Methods: Patients with clinically isolated syndrome or relapsing remitting MS who were treated with either fingolimod or natalizumab were identified in the MSBase registry. Patien..

View full abstract