Journal article
Brain-wide visual habituation networks in wild type and fmr1 zebrafish
E Marquez-Legorreta, L Constantin, M Piber, IA Favre-Bulle, MA Taylor, AS Blevins, J Giacomotto, DS Bassett, GC Vanwalleghem, EK Scott
Nature Communications | NATURE PORTFOLIO | Published : 2022
Open access
Abstract
Habituation is a form of learning during which animals stop responding to repetitive stimuli, and deficits in habituation are characteristic of several psychiatric disorders. Due to technical challenges, the brain-wide networks mediating habituation are poorly understood. Here we report brain-wide calcium imaging during larval zebrafish habituation to repeated visual looming stimuli. We show that different functional categories of loom-sensitive neurons are located in characteristic locations throughout the brain, and that both the functional properties of their networks and the resulting behavior can be modulated by stimulus saliency and timing. Using graph theory, we identify a visual circ..
View full abstractRelated Projects (1)
Grants
Awarded by Consejo Nacional de Ciencia y Tecnología
Funding Acknowledgements
We thank Ulrike Siebeck for conceptual discussion about this project and Scott lab members for feedback on the manuscript. Support was provided by an NHMRC Project Grant (APP1066887), ARC Future Fellowship (FT110100887), a Simons Foundation Pilot Award (399432), a Simons Foundation Research Award (625793), and two ARC Discovery Project Grants (DP140102036 & DP110103612) to E.K.S. The research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number R01NS118406 to E.K.S. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Support was also provided by the Australian National Fabrication Facility (ANFF), QLD node, and by Support was provided by a Rebecca Cooper Medical Research Project Grant No PG2019405 and a NHMRC Emerging Leader Fellowship No. 1174145 to J.G. E.M.-L. gratefully acknowledges funding for postgraduate studies provided by the Mexican National Council for Science and Technology (CONACYT) and The University of Queensland. D.S.B. would like to acknowledge the Army Research Office (BassettW911NF-14-1-0679 and Grafton-W911NF-16-1-0474).