Journal article
Optical tweezers across scales in cell biology
IA Favre-Bulle, EK Scott
Trends in Cell Biology | CELL PRESS | Published : 2022
Abstract
Optical tweezers (OT) provide a noninvasive approach for delivering minute physical forces to targeted objects. Controlling such forces in living cells or in vitro preparations allows for the measurement and manipulation of numerous processes relevant to the form and function of cells. As such, OT have made important contributions to our understanding of the structures of proteins and nucleic acids, the interactions that occur between microscopic structures within cells, the choreography of complex processes such as mitosis, and the ways in which cells interact with each other. In this review, we highlight recent contributions made to the field of cell biology using OT and provide basic desc..
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Awarded by National Institutes of Health
Funding Acknowledgements
We thank Julia Horsfield for valuable feedback on this review. E.K.S. is supported by an National Health and Medical Research Council (NHMRC) Project Grant (APP1066887), a Simons Foundation Research Award (625793), and two Australian Research Council (ARC) Discovery Project Grants (DP140102036 and DP110103612). This publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number R01NS118406 to E.K.S. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.