Journal article
Sound generation in zebrafish with Bio-Opto-Acoustics
IA Favre-Bulle, MA Taylor, E Marquez-Legorreta, G Vanwalleghem, RE Poulsen, H Rubinsztein-Dunlop, EK Scott
Nature Communications | NATURE RESEARCH | Published : 2020
Open access
Abstract
Hearing is a crucial sense in underwater environments for communication, hunting, attracting mates, and detecting predators. However, the tools currently used to study hearing are limited, as they cannot controllably stimulate specific parts of the auditory system. To date, the contributions of hearing organs have been identified through lesion experiments that inactivate an organ, making it difficult to gauge the specific stimuli to which each organ is sensitive, or the ways in which inputs from multiple organs are combined during perception. Here, we introduce Bio-Opto-Acoustic (BOA) stimulation, using optical forces to generate localized vibrations in vivo, and demonstrate stimulation of ..
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Grants
Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
Support was provided by an NHMRC Project Grant (APP1066887), a Simons Foundation Pilot Award (399432), a Simons Foundation Research Award (625793), and two ARC Discovery Project Grants (DP140102036 & DP110103612) to E.K.S.; an NHMRC Project Grant (APP1165173) to E.K.S. and H.R.; an ARC Discovery Project Grant (DP180101002) to H.R.; and the Australian National Fabrication Facility (ANFF), QLD node. The research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number R01NS118406. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Nicolas P. Mauranyapin for the design of Fig. 1a. We thank members of the Scott and Rubinsztein-Dunlop groups for discussions of this manuscript.