Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents

S Imran; MR Neeland; DJ Martino; S Peng; J Koplin; SC Dharmage; MLK Tang; S Sawyer; T Dang; V McWilliam; RL Peters; S Prescott; KP Perrett; B Novakovic; R Saffery

Journal article

Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents

S Imran, MR Neeland, DJ Martino, S Peng, J Koplin, SC Dharmage, MLK Tang, S Sawyer, T Dang, V McWilliam, RL Peters, S Prescott, KP Perrett, B Novakovic, R Saffery

Immunology and Cell Biology | WILEY | Published : 2023

DOI: 10.1111/imcb.12628

Abstract

Childhood is a critical period of immune development. During this time, naïve CD4 (nCD4) T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described. We investigated genome-wide DNA methylation (DNAm) changes associated with nCD4 T activation following 72 h culture in media+anti-CD3/CD28 beads in healthy infants (aged 12 months, n = 18) and adolescents (aged 10–15 years, n = 15). We integrated these data with transcript..

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University of Melbourne Researchers

Melanie Neeland Author

Shyamali Dharmage Author

Mimi Tang Author

Susan Sawyer Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was funded by an NHMRC (Australia) Project Grant (#1165073) to RS, MN and BN. The SchoolNuts study was funded by an NHMRC Project Grant (#1047396), and the HealthNuts study was funded by an NHMRC (Australia) Project Grant (#1006215). BN is supported by an NHMRC (Australia) Investigator Grant (#1173314). KP is supported by a NHMRC (Australia) Investigator Grant (#2008911) and a Melbourne Children's Clinician Scientist Fellowship. JK is supported by an NHMRC (Australia) Investigator Grant (#1158699). SCD is supported by NHMRC (Australia) Project Grants (#1193993 and #1170958). RLP is supported by an NHMRC (Australia) Early Career Fellowship (#1160779). We thank the children and parents that participated in the HealthNuts study; as well as the students, parents and schools that participated in the SchoolNuts study. Open access publishing facilitated by The University of Melbourne, as part of the Wiley The University of Melbourne agreement via the Council of Australian University Librarians. Funding for this work was provided by the NHMRC (Australia) Project Grant (#1165073). The SchoolNuts study was funded by an NHMRC Project Grant (#1047396), and the HealthNuts study was funded by an NHMRC (Australia) Project Grant (#1006215).