Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

K Merritt; RA McCutcheon; A Aleman; S Ashley; K Beck; W Block; OJN Bloemen; F Borgan; C Boules; JR Bustillo; AA Capizzano; JM Coughlin; A David; C de la Fuente-Sandoval; A Demjaha; K Dempster; KQ Do; F Du; P Falkai; B Galińska-Skok; J Gallinat; C Gasparovic; CE Ginestet; N Goto; A Graff-Guerrero; BC Ho; O Howes; S Jauhar; P Jeon; T Kato; CA Kaufmann; LS Kegeles; MS Keshavan; SY Kim; B King; H Kunugi; J Lauriello; P León-Ortiz; E Liemburg; ME Mcilwain; G Modinos; E Mouchlianitis; J Nakamura; I Nenadic; D Öngür; M Ota; L Palaniyappan; C Pantelis; T Patel; E Plitman; S Posporelis; SE Purdon; JR Reichenbach; PF Renshaw; F Reyes-Madrigal; BR Russell; A Sawa; M Schaefer; DC Shungu; S Smesny; JA Stanley; J Stone; A Szulc; R Taylor; KN Thakkar; J Théberge; PG Tibbo; T van Amelsvoort; J Walecki; PC Williamson; SJ Wood; L Xin; H Yamasue; P McGuire; A Egerton; C de la Fuente-Sandoval; PK McGuire

Journal article

Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

K Merritt, RA McCutcheon, A Aleman, S Ashley, K Beck, W Block, OJN Bloemen, F Borgan, C Boules, JR Bustillo, AA Capizzano, JM Coughlin, A David, C de la Fuente-Sandoval, A Demjaha, K Dempster, KQ Do, F Du, P Falkai, B Galińska-Skok Show all

Molecular Psychiatry | SPRINGERNATURE | Published : 2023

DOI: 10.1038/s41380-023-01991-7

Open access

Abstract

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in extent between patients. It is unclear whether inter-individual variability in glutamate is greater in schizophrenia than the general population. We conducted meta-analyses to assess (1) variability of glutamate measures in patients relative to controls (log coefficient of variation ratio: CVR); (2) standardised mean differences (SMD) using Hedges g; (3) modal distribution of individual-level glutamate data (Hartigan’s unimodality dip test). MEDLINE and EMBASE databases were searched from inception to September 2022 for proton magnetic resonance spectroscopy (1H-MRS) studies reporting glutamate, glu..

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University of Melbourne Researchers

Christos Pantelis Author

Stephen Wood Author

Grants

Awarded by King’s College London

Funding Acknowledgements

This work was supported by MRC Grant Reference MR/S003436/1 (TD) and Medical Research Council grant MR/L003988/1 (AE). RM is funded by an NIHR clinical lectureship. OH is funded by Medical Research Council-UK (no.MC_A656_5QD30_2135), Maudsley Charity (no. 666), and Wellcome Trust (no.094849/Z/10/Z). This study presents independent research funded in part by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley National Health Service (NHS) Foundation Trust and King's College London.