Journal article
Age-dependent associations of human milk oligosaccharides with body size and composition up to 4 years of age
T Mansell, A Furst, M O'Hely, M Chang, AL Ponsonby, P Vuillermin, ML Tang, D Burgner, R Saffery, L Bode
American Journal of Clinical Nutrition | Published : 2023
Abstract
Background: Human milk oligosaccharides (HMOs) are major components of human milk that may mediate its beneficial effects on infant growth. Objectives: To investigate relationships between HMO concentrations in milk at 6 wk postpartum and anthropometry to 4 y of age in human milk-fed infants. Methods: Milk samples were collected from 292 mothers at 6 wk (median 6.0 wk; range 3.3, 11.1] postpartum in a longitudinal, population-derived cohort. Of the infants, 171 were exclusively human milk-fed to 3 mo of age and 127 to 6 mo. Concentrations of 19 HMOs were quantified using high-performance liquid chromatography. Maternal secretor status (n = 221 secretors) was determined from 2’-fucosyllactose..
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Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development
Funding Acknowledgements
Funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund-Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited and the Percy Baxter Charitable Trust, Perpetual Trustees, and the Minderoo Foundation. In addition, in-kind support was provided by the Cotton On Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The funding bodies were not involved in the study design; collection, analysis, and interpretation of the data; writing and preparation of the manuscript; or decision to submit the manuscript for publication.