Journal article
The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency: Special Issue: Emerging Investigators
B Lin, A Hung, W Singleton, KK Darmawan, R Moses, B Yao, H Wu, A Barlow, MA Sani, AJ Sloan, MA Hossain, JD Wade, Y Hong, NM O'Brien-Simpson, W Li
Aggregate | Published : 2023
DOI: 10.1002/agt2.329
Abstract
Antimicrobial peptides (AMPs) are potentially powerful alternatives to conventional antibiotics in combating multidrug resistance, given their broad spectrum of activity. They mainly interact with cell membranes through surface electrostatic potentials and the formation of secondary structures, resulting in permeability and destruction of target microorganism membranes. Our earlier work showed that two leading AMPs, MSI-78 (4–20) and pardaxin (1–22), had potent antimicrobial activity against a range of bacteria. It is known that the attachment of moderate-length lipid carbon chains to cationic peptides can further improve the functionality of these peptides through enhanced interactions with..
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Grants
Awarded by Australian Government
Funding Acknowledgements
<STRONG> </STRONG>The National Health and Medical Research Council, Grant/Award Numbers: APP2018256, APP1142472, APP1158841, APP1185426; Australian Research Council, Grant/Award Numbers: FT210100271, DP210102781, DP160101312, LE200100163; Cancer Council Victoria funding, Grant/Award Number: APP1163284; Australia-China Science and Research Fund-Joint Research Centre on Personal Health Technologies, Grant/Award Number: ACSRF65777; Australian Dental Research Foundation Grant; Pawsey Supercomputing Centre; National Computational Infrastructure; Australian National Fabrication Facility, Grant/Award Number: VictorianNode