Predicting the efficacy of variant-modified COVID-19 vaccine boosters

DS Khoury; SS Docken; K Subbarao; SJ Kent; MP Davenport; D Cromer

Journal article

Predicting the efficacy of variant-modified COVID-19 vaccine boosters

DS Khoury, SS Docken, K Subbarao, SJ Kent, MP Davenport, D Cromer

Nature Medicine | Published : 2023

DOI: 10.1038/s41591-023-02228-4

Abstract

Booster vaccination for the prevention of Coronavirus Disease 2019 (COVID-19) is required to overcome loss of protection due to waning immunity and the spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Studies have assessed the ability of existing ancestral-based vaccines as well as novel variant-modified vaccine regimens to boost immunity to different variants, and a crucial question is to assess the relative benefits of these different approaches. Here we aggregate data on neutralization titers from 14 reports (three published papers, eight preprints, two press releases and notes of one advisory committee meeting) comparing booster vaccination with the ..

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University of Melbourne Researchers

Kanta Subbarao Author

Stephen Kent Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by Australian NHMRC program grant 1149990 to S.J.K. and M.P.D.; Australian MRFF award 2005544 to S.J.K. and M.P.D.; and MRFF 2015313 to M.P.D. D.C., K.S., M.P.D. and S.J.K. are supported by NHMRC fellowships (numbers 1173528, 1177174, 1173027 and 1136452, respectively). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.