Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials

V Yogendrakumar; L Churilov; PJ Mitchell; TJ Kleinig; N Yassi; V Thijs; T Wu; D Shah; P Bailey; HM Dewey; PMC Choi; A Ma; T Wijeratne; C Garcia-Esperon; G Cloud; RV Chandra; DJ Cordato; B Yan; G Sharma; PM Desmond; MW Parsons; GA Donnan; SM Davis; BCV Campbell; R Dowling; S Bush; R Scroop; M Simpson; M Brooks; H Asadi; T Ang; F Miteff; C Levi; E Rodrigues; H Zhao; F Ng; F Alemseged; P Salvaris; H Rice; L De Villiers; H Brown; K Redmond; D Leggett; J Fink; W Collecutt; T Kraemer; C Muller; A Coulthard; K Mitchell; J Clouston; K Mahady; D Field; B O'Brien; B Clissold; A Clissold; L Bolitho; L Bonavia; A Bhattacharya; A Wright; A Mamun; F O'Rourke; J Worthington; A Wong; H Ma; T Phan; W Chong; LA Slater; M Krause; T Harrington; K Faulder; B Steinfort; C Bladin

Journal article

Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials

V Yogendrakumar, L Churilov, PJ Mitchell, TJ Kleinig, N Yassi, V Thijs, T Wu, D Shah, P Bailey, HM Dewey, PMC Choi, A Ma, T Wijeratne, C Garcia-Esperon, G Cloud, RV Chandra, DJ Cordato, B Yan, G Sharma, PM Desmond Show all

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2023

DOI: 10.1212/WNL.0000000000207138

Abstract

Background and ObjectivesThe safety and efficacy of tenecteplase (TNK) in patients with tandem lesion (TL) stroke is unknown. We performed a comparative analysis of TNK and alteplase in patients with TLs.MethodsWe first compared the treatment effect of TNK and alteplase in patients with TLs using individual patient data from the EXTEND-IA TNK trials. We evaluated intracranial reperfusion at initial angiographic assessment and 90-day modified Rankin scale (mRS) with ordinal logistic and Firth regression models. Because 2 key outcomes, mortality and symptomatic intracranial hemorrhage (sICH), were few in number among those who received alteplase in the EXTEND-IA TNK trials, we generated pooled..

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University of Melbourne Researchers

Leonid Churilov Author

Peter Mitchell Author

Nawaf Yassi Author

Vincent Thijs Author

Grants

Awarded by Bayer

Funding Acknowledgements

This study did not receive study-specific funding. The EXTEND-IA TNK trials received funding from the National Health and Medical Research Council Australia (GNT1113352, GNT1111972). V. Yogendrakumar is supported by a Canadian Institute of Health Research Fellowship Award, a University of Melbourne Research Scholarship, and a Detweiler Travelling Fellowship.