Journal article
An Engineered Nanosugar Enables Rapid and Sustained Glucose-Responsive Insulin Delivery in Diabetic Mice
R Xu, SK Bhangu, KC Sourris, D Vanni, MA Sani, JA Karas, K Alt, B Niego, A Ale, QA Besford, B Dyett, J Patrick, I Carmichael, JE Shaw, F Caruso, ME Cooper, CE Hagemeyer, F Cavalieri
Advanced Materials | Published : 2023
Abstract
Glucose-responsive insulin-delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge-switchable phytoglycogen nanoparticles capable of glucose-stimulated insulin release are engineered. The nanoparticles are “nanosugars” bearing glucose-sensitive phenylboronic acid groups and amine moieties that allow effective complexation with insulin (≈95% loading capacity) to form nanocomplexes. A single subcutaneous injection of nanocomplexes shows a rapid and efficient response to a glucose challenge in two distinct ..
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Grants
Awarded by University of Melbourne
Funding Acknowledgements
R.X. and S.K.B. contributed equally to this work. This work was supported by the National Health and Medical Research Council of Australia (Ideas Grant to C.E.H. and F.Cavalieri GNT1181440, Senior Research Fellowship to C.E.H. GNT1154270, Senior Principal Research Fellowship to F. Caruso GNT1135806). F. Cavalieri acknowledges the award of an RMIT Vice Chancellor Senior Research Fellowship. R.X. was supported by a Monash University Senior Postdoctoral Fellowship. This work received funding from the European Union Horizon 2020 Research and Innovation Program under the H2020 Marie Sklodowska-Curie Actions grant agreement no. 872233 ("PEPSAMATE"). The authors thank Margaret Hibbs and Evelyn Tsantikos for advice on the lymphatic system. The authors thank Monash University's Micro-Imaging Platform (Stephen Cody), AMREP Flow Cytometry Core Facility (Eva Orlowski-Oliver) and Histology Platform (Camilla Cohen). This work was performed in part at the Materials Characterization and Fabrication Platform (MCFP) and Bio21 Ian Holmes imaging Center at The University of Melbourne.Open access publishing facilitated by RMIT University, as part of the Wiley - RMIT University agreement via the Council of Australian University Librarians