Atrial Fibrillation Ablation for Heart Failure With Preserved Ejection Fraction: A Randomized Controlled Trial

D Chieng; H Sugumar; L Segan; C Tan; D Vizi; S Nanayakkara; A Al-Kaisey; J Hawson; S Prabhu; A Voskoboinik; S Finch; JB Morton; G Lee; J Mariani; A La Gerche; AJ Taylor; E Howden; PM Kistler; JM Kalman; DM Kaye; LH Ling

Journal article

Atrial Fibrillation Ablation for Heart Failure With Preserved Ejection Fraction: A Randomized Controlled Trial

D Chieng, H Sugumar, L Segan, C Tan, D Vizi, S Nanayakkara, A Al-Kaisey, J Hawson, S Prabhu, A Voskoboinik, S Finch, JB Morton, G Lee, J Mariani, A La Gerche, AJ Taylor, E Howden, PM Kistler, JM Kalman, DM Kaye Show all

Jacc Heart Failure | Published : 2023

DOI: 10.1016/j.jchf.2023.01.008

Abstract

Background: Patients with heart failure with preserved ejection fraction (HFpEF) frequently develop atrial fibrillation (AF). There are no randomized trials examining the effects of AF ablation on HFpEF outcomes. Objectives: The aim of this study is to compare the effects of AF ablation vs usual medical therapy on markers of HFpEF severity, including exercise hemodynamics, natriuretic peptide levels, and patient symptoms. Methods: Patients with concomitant AF and HFpEF underwent exercise right heart catheterization and cardiopulmonary exercise testing. HFpEF was confirmed with pulmonary capillary wedge pressure (PCWP) of 15 mm Hg at rest or ≥25 mm Hg on exercise. Patients were randomized to ..

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University of Melbourne Researchers

Sue Finch Author

Geoffrey Lee Author

Andre La Gerche Author

Erin Howden Author

Grants

Funding Acknowledgements

Dr Chieng is supported by co-funded NHMRC/NHF post-graduate scholarship. Dr Prabhu has received an NHMRC Post-Doctoral Research Fellowship. Dr Voskoboinik has received a National Heart Foundation Early Career Fellowship. Dr Lee has received consulting fees from Biosense Webster. Dr Kistler has received funding from Abbott Medical for consultancy and speaking engagements; and has served on the advisory board with fellowship support from Biosense Webster. Dr Kalman has received fellowship support from Medtronic and Biosense Webster. Dr Kaye has received an NHMRC Investigator Grant. Dr Ling has received funding from Abbott Medical for project funding, consultancy, and speaking engagements; and has received funding from Abbott Medical for project funding, consultancy, and speaking engagements. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.