Review article: the future of microbiome-based therapeutics

Abstract

Background: From consumption of fermented foods and probiotics to emerging applications of faecal microbiota transplantation, the health benefit of manipulating the human microbiota has been exploited for millennia. Despite this history, recent technological advances are unlocking the capacity for targeted microbial manipulation as a novel therapeutic. Aim: This review summarises the current developments in microbiome-based medicines and provides insight into the next steps required for therapeutic development. Methods: Here we review current and emerging approaches and assess the capabilities and weaknesses of these technologies to provide safe and effective clinical interventions. Key lite..