Utility of risk of malignancy indices to predict ovarian malignancy in children and adolescents

Abstract

Background Identifying malignant ovarian masses preoperatively in young women can prove difficult due to their nonspecific presentation in this population (1). Objective To describe (i) the clinicopathological predictors of malignancy in surgically removed ovarian masses in women ≤ 21 years of age; (ii)the ability of three risk models to distinguish malignant (including borderline) from benign tumours. Methods A 30-year retrospective analysis of surgically removed ovarian masses in females ≤ 21 years at the Royal Children's Hospital and the Royal Women's Hospital Melbourne. External validation of risk of malignancy scores were undertaken. These included RMI2 (Risk of Malignancy Index 2, [men..