Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

CJ Murray; KS Ikuta; F Sharara; L Swetschinski; G Robles Aguilar; A Gray; C Han; C Bisignano; P Rao; E Wool; SC Johnson; AJ Browne; MG Chipeta; F Fell; S Hackett; G Haines-Woodhouse; BH Kashef Hamadani; EAP Kumaran; B McManigal; R Agarwal; S Akech; S Albertson; J Amuasi; J Andrews; A Aravkin; E Ashley; F Bailey; S Baker; B Basnyat; A Bekker; R Bender; A Bethou; J Bielicki; S Boonkasidecha; J Bukosia; C Carvalheiro; C Castañeda-Orjuela; V Chansamouth; S Chaurasia; S Chiurchiù; F Chowdhury; AJ Cook; B Cooper; TR Cressey; E Criollo-Mora; M Cunningham; S Darboe; NPJ Day; M De Luca; K Dokova; A Dramowski; SJ Dunachie; T Eckmanns; D Eibach; A Emami; N Feasey; N Fisher-Pearson; K Forrest; D Garrett; P Gastmeier; AZ Giref; RC Greer; V Gupta; S Haller; A Haselbeck; SI Hay; M Holm; S Hopkins; KC Iregbu; J Jacobs; D Jarovsky; F Javanmardi; M Khorana; N Kissoon; E Kobeissi; T Kostyanev; F Krapp; R Krumkamp; A Kumar; HH Kyu; C Lim; D Limmathurotsakul; MJ Loftus; M Lunn; J Ma; N Mturi; T Munera-Huertas; P Musicha; MM Mussi-Pinhata; T Nakamura; R Nanavati; S Nangia; P Newton; C Ngoun; A Novotney; D Nwakanma; CW Obiero; A Olivas-Martinez; P Olliaro; E Ooko

Journal article

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

CJ Murray, KS Ikuta, F Sharara, L Swetschinski, G Robles Aguilar, A Gray, C Han, C Bisignano, P Rao, E Wool, SC Johnson, AJ Browne, MG Chipeta, F Fell, S Hackett, G Haines-Woodhouse, BH Kashef Hamadani, EAP Kumaran, B McManigal, R Agarwal Show all

Lancet | Published : 2022

DOI: 10.1016/S0140-6736(21)02724-0

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Abstract

Background: Antimicrobial resistance (AMR) poses a major threat to human health around the world. Previous publications have estimated the effect of AMR on incidence, deaths, hospital length of stay, and health-care costs for specific pathogen–drug combinations in select locations. To our knowledge, this study presents the most comprehensive estimates of AMR burden to date. Methods: We estimated deaths and disability-adjusted life-years (DALYs) attributable to and associated with bacterial AMR for 23 pathogens and 88 pathogen–drug combinations in 204 countries and territories in 2019. We obtained data from systematic literature reviews, hospital systems, surveillance systems, and other sourc..

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