Journal article
Pharmacological Emergency management of Agitation in Children and Young people: Protocol for a randomised controlled trial of intraMuscular medication (PEAChY-M)
EM Bourke, ML Borland, A Kochar, S George, D Shellshear, S Jani, K Perkins, D Tham, MS Gordon, K Klein, C Prakash, K Lee, A Davidson, JC Knott, S Craig, FE Babl
BMJ Open | Published : 2023
Abstract
Introduction Acute severe behavioural disturbance (ASBD) is a condition seen with increasing frequency in emergency departments (EDs) in adults and young people. Despite the increasing number of presentations and significant associated risks to patients, families and caregivers, there is limited evidence to guide the most effective pharmacological management in children and adolescents. The aim of this study is to determine whether a single dose of intramuscular olanzapine is more effective than intramuscular droperidol at successfully sedating young people with ASBD requiring intramuscular sedation. Methods and analysis This study is a multicentre, open-label, superiority randomised control..
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Grants
Awarded by State Government of Victoria
Funding Acknowledgements
This study is being funded by the Medical Research Futures Fund Million Minds Grant, Canberra, Australia (GNT1179137), the Western Australian Child Research Fund Grant (Round 8), Perth, Australia (N/A) and an Emergency Medicine Foundation (EMF) Grant (Round 38), Brisbane, Queensland (EMLE-234R38-2022). EMB is funded by an NHMRC postgraduate scholarship (GNT2005279). FEB is funded by a grant from the Royal Children's Hospital Foundation and a NHMRC Investigator Grant (GNT2017605). This study is supported by the Melbourne Children's Trials Centre at MCRI. The Royal Children's Hospital and the MCRI are supported by the Victorian Government's Operational Infrastructure Support, Australia (N/A).