Journal article
Longitudinal Asthma Phenotypes from Childhood to Middle-Age A Population-based Cohort Study
DJ Tan, CJ Lodge, EH Walters, AJ Lowe, DS Bui, G Bowatte, J Pham, B Erbas, J Hui, GS Hamilton, PS Thomas, M Hew, G Washko, R Wood-Bake, MJ Abramson, JL Perret, SC Dharmage
American Journal of Respiratory and Critical Care Medicine | Published : 2023
Abstract
Rationale: Asthma is a heterogeneous condition, and longitudinal phenotyping may provide new insights into the origins and outcomes of the disease. Objectives: We aimed to characterize the longitudinal phenotypes of asthma between the first and sixth decades of life in a population-based cohort study. Methods: Respiratory questionnaires were collected at seven time points in the TAHS (Tasmanian Longitudinal Health Study) when participants were aged 7, 13, 18, 32, 43, 50, and 53 years. Current-asthma and ever-asthma status was determined at each time point, and group-based trajectory modeling was used to characterize distinct longitudinal phenotypes. Linear and logistic regression models were..
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Grants
Awarded by Asthma Australia
Funding Acknowledgements
Supported by funds from the National Health and Medical Research Council of Australia (grant 1021275); the University of Melbourne; the Clifford Craig Foundation; the Victorian, Queensland, and Tasmanian Asthma Foundations; the Royal Hobart Hospital Research Foundation; the Helen MacPherson Smith Trust; GlaxoSmithKline; Asthma Australia; and a National Health and Medical Research Council Postgraduate Scholarship and Royal Australian College of Physicians Woolcock Scholarship (D.J.T.). The funding bodies had no direct role in the conduct of the study, statistical analysis or interpretation of the data, and preparation or approval of the manuscript.