Bi-modal system-on-chip platform for bilirubin monitoring by using photometric and temporal degradation approaches

Abstract

Hyperbilirubinemia in infants and cirrhosis in adults remain major global causes of sickness and death, predominantly for people living in areas with poor or limited healthcare resources. Clinically, the two conditions require measuring levels of bilirubin in blood for diagnostic and prognostic purposes. While the existing techniques provide the most comprehensive pathology-lab results, they suffer from complexity and size requirements, and measurements are impractical for point-of-Care (PoC) testing. Furthermore, the existing transcutaneous devices (for neonates) are pricey, preventing the possibility of dissemination for home health care applications. This study uses an integrated and all-..