Journal article
Ethnic differences in cellular and humoral immune responses to SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis
CA Martin, J Nazareth, A Jarkhi, D Pan, M Das, N Logan, S Scott, L Bryant, N Abeywickrama, O Adeoye, A Ahmed, A Asif, S Bandi, N George, M Gohar, LJ Gray, R Kaszuba, J Mangwani, M Martin, A Moorthy Show all
Eclinicalmedicine | Published : 2023
Open access
Abstract
Background: Few studies have compared SARS-CoV-2 vaccine immunogenicity by ethnic group. We sought to establish whether cellular and humoral immune responses to SARS-CoV-2 vaccination differ according to ethnicity in UK Healthcare workers (HCWs). Methods: In this cross-sectional analysis, we used baseline data from two immunological cohort studies conducted in HCWs in Leicester, UK. Blood samples were collected between March 3, and September 16, 2021. We excluded HCW who had not received two doses of SARS-CoV-2 vaccine at the time of sampling and those who had serological evidence of previous SARS-CoV-2 infection. Outcome measures were SARS-CoV-2 spike-specific total antibody titre, neutrali..
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Awarded by NIHR Imperial Biomedical Research Centre
Funding Acknowledgements
<STRONG> </STRONG>We would like to thank all the participants who have taken part in this study when the NHS is under immense pressure. We would also like to thank all the staff in the Research Space at Leicester Royal Infirmary, without whom this work would not have been possible. LJG and KK are supported by the National Institute for Health and Care Research (NIHR) Applied Research Collaboration East Midlands (ARC EM) and Leicester NIHR Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. DIRECT and BELIEVE have received funding from UK Research and Innovation (UKRI) through the COVID-19 National Core Studies Immunity (NCSi) programme (MC_PC_20060). BELIEVE was originally established as an influenza study funded by Sanofi. JN is an NIHR Academic Clinical Fellow. DP is an NIHR doctoral fellow. MP is funded by a NIHR Development and Skills Enhancement Award.