Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine

G Deliyannis; NA Gherardin; CY Wong; SL Grimley; JP Cooney; SJ Redmond; P Ellenberg; KC Davidson; FL Mordant; T Smith; M Gillard; E Lopez; J McAuley; CW Tan; JJ Wang; W Zeng; M Littlejohn; R Zhou; J Fuk-Woo Chan; ZW Chen; AE Hartwig; R Bowen; JM Mackenzie; E Vincan; J Torresi; K Kedzierska; CW Pouton; TP Gordon; LF Wang; SJ Kent; AK Wheatley; SR Lewin; K Subbarao; AW Chung; M Pellegrini; T Munro; T Nolan; S Rockman; DC Jackson; DFJ Purcell; DI Godfrey

Journal article

Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine

G Deliyannis, NA Gherardin, CY Wong, SL Grimley, JP Cooney, SJ Redmond, P Ellenberg, KC Davidson, FL Mordant, T Smith, M Gillard, E Lopez, J McAuley, CW Tan, JJ Wang, W Zeng, M Littlejohn, R Zhou, J Fuk-Woo Chan, ZW Chen Show all

Ebiomedicine | Published : 2023

DOI: 10.1016/j.ebiom.2023.104574

Abstract

Background: The SARS-CoV-2 global pandemic has fuelled the generation of vaccines at an unprecedented pace and scale. However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability during storage and transport, waning vaccine-induced immunity, and concerns about infrequent adverse events associated with existing vaccines. Methods: We report on a protein subunit vaccine comprising the receptor-binding domain (RBD) of the ancestral SARS-CoV-2 spike protein, dimerised with an immunoglobulin IgG1 Fc domain. These were tested in conjunction with three different adjuvants: a TLR2 agonist R4-Pam2Cys, an NKT cell agonist glycolipid α-Galactosylcerami..

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University of Melbourne Researchers

Georgia Deliyannis Author

Nicholas Gherardin Author

Chinn Yi Wong Author

Samantha Grimley Author

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Grants

Awarded by Australian Government

Funding Acknowledgements

This work was supported by grants from the Medical Research Future Fund (MRFF) (2005846) , The Jack Ma Foundation, National Health and Medical Research Council of Australia (NHMRC; 1113293) and Singapore National Medical Research Council (MOH-COVID19RF-003) . Individual researchers were supported by an NHMRC Senior Principal Research Fellowship (1117766) , NHMRC Investigator Awards (2008913 and 1173871) , Australian Research Council Discovery Early Career Research Award (ARC DECRA; DE210100705) and philanthropic awards from IFM investors and the A2 Milk Company.