Journal article
Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity
I Gil-Miravet, Á Núñez-Molina, M Navarro-Sánchez, E Castillo-Gómez, F Ros-Bernal, AL Gundlach, FE Olucha-Bordonau
Brain Structure and Function | SPRINGER HEIDELBERG | Published : 2023
Open access
Abstract
Nucleus incertus (NI) neurons in the pontine tegmentum give rise to ascending forebrain projections and express the neuropeptide relaxin-3 (RLN3) which acts via the relaxin-family peptide 3 receptor (RXFP3). Activity in the hippocampus and entorhinal cortex can be driven from the medial septum (MS), and the NI projects to all these centers, where a prominent pattern of activity is theta rhythm, which is related to spatial memory processing. Therefore, we examined the degree of collateralization of NI projections to the MS and the medial temporal lobe (MTL), comprising medial and lateral entorhinal cortex (MEnt, LEnt) and dentate gyrus (DG), and the ability of the MS to drive entorhinal theta..
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Awarded by Fundación Alicia Koplowitz
Funding Acknowledgements
This research was funded by the Postdoctoral Program of the UJI POSDOC/2021/19 (IG-M); UJI Predoctoral Program PREDOC/2021/19 (MN-S); Fundacion Alicia Koplowitz, Spain, grant number 19I436 (FEO-B, FR-B, EC-G); the Spanish Ministerio de Ciencia, Innovacion y Universidades, grant number RTI2018-095698-B-I00 (FEO-B, IG-M, FR-B, EC-G); AICO Generalitat Valenciana, grant number AICO/2021/246 (EC-G, FO-B, FR-B), National Health and Medical Research Council of Australia, grant number (ALG), the Spanish Ministerio de Ciencia, Innovacion y Universidades, grant number PID2019-107809RB-I00 (AN-M) and Universitat Jaume I, grant numbers UJI-A2017-17 (FR-B) and UJI-B2019-54 (FEO-B).