Journal article
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.
James Yarmolinsky, Jamie W Robinson, Daniela Mariosa, Ville Karhunen, Jian Huang, Niki Dimou, Neil Murphy, Kimberley Burrows, Emmanouil Bouras, Karl Smith-Byrne, Sarah J Lewis, Tessel E Galesloot, Lambertus A Kiemeney, Sita Vermeulen, Paul Martin, Demetrius Albanes, Lifang Hou, Polly A Newcomb, Emily White, Alicja Wolk Show all
medRxiv | Published : 2023
Abstract
BACKGROUND: Tumour-promoting inflammation is a "hallmark" of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. METHODS: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,162 cancer cases and up to 824,556 controls. ..
View full abstractRelated Projects (2)
Grants
Awarded by NHGRI NIH HHS
Awarded by NCI NIH HHS
Awarded by NHLBI NIH HHS
Awarded by Medical Research Council
Awarded by Cancer Research UK
Awarded by Intramural NIH HHS
Awarded by NIH HHS
Awarded by NIDDK NIH HHS
Awarded by WHI NIH HHS
Awarded by NIA NIH HHS
Awarded by NIEHS NIH HHS
Awarded by NCATS NIH HHS