Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

S Koutros; LA Kiemeney; P Pal Choudhury; RL Milne; E Lopez de Maturana; Y Ye; V Joseph; O Florez-Vargas; L Dyrskjøt; J Figueroa; D Dutta; GG Giles; MAT Hildebrandt; K Offit; M Kogevinas; E Weiderpass; ML McCullough; ND Freedman; D Albanes; C Kooperberg; VK Cortessis; MR Karagas; A Johnson; MR Schwenn; D Baris; H Furberg; DF Bajorin; O Cussenot; G Cancel-Tassin; S Benhamou; P Kraft; S Porru; A Carta; T Bishop; MC Southey; G Matullo; T Fletcher; R Kumar; JA Taylor; P Lamy; F Prip; M Kalisz; SJ Weinstein; JG Hengstler; S Selinski; M Harland; M Teo; AE Kiltie; A Tardón; C Serra; A Carrato; R García-Closas; J Lloreta; A Schned; P Lenz; E Riboli; P Brennan; A Tjønneland; T Otto; D Ovsiannikov; F Volkert; SH Vermeulen; KK Aben; TE Galesloot; C Turman; I De Vivo; E Giovannucci; DJ Hunter; C Hohensee; R Hunt; AV Patel; WY Huang; G Thorleifsson; M Gago-Dominguez; P Amiano; K Golka; MC Stern; W Yan; J Liu; SA Li; S Katta; A Hutchinson; B Hicks; WA Wheeler; MP Purdue; KA McGlynn; CM Kitahara; CA Haiman; MH Greene; T Rafnar; N Chatterjee; SJ Chanock; X Wu; FX Real; DT Silverman; M Garcia-Closas; K Stefansson; L Prokunina-Olsson; N Malats; N Rothman

Journal article

Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

S Koutros, LA Kiemeney, P Pal Choudhury, RL Milne, E Lopez de Maturana, Y Ye, V Joseph, O Florez-Vargas, L Dyrskjøt, J Figueroa, D Dutta, GG Giles, MAT Hildebrandt, K Offit, M Kogevinas, E Weiderpass, ML McCullough, ND Freedman, D Albanes, C Kooperberg Show all

European Urology | Published : 2023

DOI: 10.1016/j.eururo.2023.04.020

Abstract

Background: Genomic regions identified by genome-wide association studies (GWAS) for bladder cancer risk provide new insights into etiology. Objective: To identify new susceptibility variants for bladder cancer in a meta-analysis of new and existing genome-wide genotype data. Design, setting, and participants: Data from 32 studies that includes 13,790 bladder cancer cases and 343, 502 controls of European ancestry were used for meta-analysis. Outcome measurements and statistical analyses: Log-additive associations of genetic variants were assessed using logistic regression models. A fixed-effects model was used for meta-analysis of the results. Stratified analyses were conducted to evaluate ..

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University of Melbourne Researchers

Roger Milne Author

Graham Giles Author

Melissa Southey Author

Related Projects (3)

PRECISION PUBLIC HEALTH FOR MAJOR CANCERS - NOVEL APPROACHES TO BUILDING THE GENETIC, EPIGENETIC AND LIFESTYLE KNOWLEDGE BASE FOR ASSESSING RISK AND PROGNOSIS

The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based..

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THE HEALTH 2020 COHORT STUDY (HEALTH 2020)

Our aim is to develop appropriate infrastructures necessary to facilitate access by researchers to the accumulated data, including questionn..

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics (ZIA CP010187-18) . The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, and contracts from the Division of Cancer Prevention, National Cancer Institute. Funding for the Nijmegen Bladder Cancer Study was supported by intramural research investment funds from Radboud University Medical Center. Work in the laboratory of Francisco X. Real is funded by Fundacion Cientifica de la Asociacion Espanola Contra el Cancer. The CNIO/UROMOL study and analyses are supported by EU-7FP (HEALTH-F2-2008-201663) and Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (#PI18/01347) . The American Cancer Society funds the creation, maintenance, and updating of the Cancer Prevention Study-II Nutrition Cohort. The Womens Health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, and 75N92021D00005. Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further augmented by Australian National Health and Medical Research Council grants 209057, 396414, and 1074383, and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the Australian Cancer Database. The funding bodies played no direct role in the study. This work was partially supported by The V Foundation for Cancer Research and The Cycle for Survival grants to Vijai Joseph and Helena Furberg. In addition, this research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748 to Memorial Sloan Kettering Cancer Center.