Journal article
Retinal alpha-synuclein accumulation correlates with retinal dysfunction and structural thinning in the A53T mouse model of Parkinson’s disease
KKN Tran, VHY Wong, A Hoang, DI Finkelstein, BV Bui, CTO Nguyen
Frontiers in Neuroscience | Published : 2023
Abstract
Abnormal alpha-synuclein (α-SYN) protein deposition has long been recognized as one of the pathological hallmarks of Parkinson’s disease’s (PD). This study considers the potential utility of PD retinal biomarkers by investigating retinal changes in a well characterized PD model of α-SYN overexpression and how these correspond to the presence of retinal α-SYN. Transgenic A53T homozygous (HOM) mice overexpressing human α-SYN and wildtype (WT) control littermates were assessed at 4, 6, and 14 months of age (male and female, n = 15–29 per group). In vivo retinal function (electroretinography, ERG) and structure (optical coherence tomography, OCT) were recorded, and retinal immunohistochemistry a..
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Grants
Awarded by U.S. Department of Defense
Funding Acknowledgements
This research was funded by U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 (US Department of Defense, CDMRP PD210055) and Australian Research Council Linkage grants (LP160100126), as well as funding through Melbourne Neuroscience Institute Interdisciplinary Seed Fund, Melbourne Research Fellowship, Melbourne Neuroscience Institute Fellowship, Melbourne School of Health Sciences Seed Funding and John Landman PhD Scholarship.