A model for malaria treatment evaluation in the presence of multiple species

CR Walker; RI Hickson; E Chang; P Ngor; S Sovannaroth; JA Simpson; DJ Price; JM McCaw; RN Price; JA Flegg; A Devine

Journal article

A model for malaria treatment evaluation in the presence of multiple species

CR Walker, RI Hickson, E Chang, P Ngor, S Sovannaroth, JA Simpson, DJ Price, JM McCaw, RN Price, JA Flegg, A Devine

Epidemics | Published : 2023

DOI: 10.1016/j.epidem.2023.100687

Abstract

Plasmodium falciparum and P. vivax are the two most common causes of malaria. While the majority of deaths and severe morbidity are due to P. falciparum, P. vivax poses a greater challenge to eliminating malaria outside of Africa due to its ability to form latent liver stage parasites (hypnozoites), which can cause relapsing episodes within an individual patient. In areas where P. falciparum and P. vivax are co-endemic, individuals can carry parasites of both species simultaneously. These mixed infections complicate dynamics in several ways: treatment of mixed infections will simultaneously affect both species, P. falciparum can mask the detection of P. vivax, and it has been hypothesised th..

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University of Melbourne Researchers

Roslyn Hickson Author

Julie Simpson Author

David Price Author

James McCaw Author

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Funding Acknowledgements

This work is supported in part by the Australian Centre for Research Excellence in Malaria Elimination (ACREME) , funded by the NHMRC (1134989) . J.A. Simpson is funded by an Australian National Health and Medical Research Council of Australia (NHMRC) Investigator Grant (1196068) . R.N. Price is a Wellcome Trust Senior Fellow in Clinical Science (200909) . This research was funded in whole, or in part, by the Wellcome Trust (200909) . For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. J.M. McCaw's research is supported by the ARC (DP170103076, DP210101920) and ACREME. J.A. Flegg's research is supported by the ARC (DP200100747, FT210100034) . A. Devine's research is supported by National Health and Medical Research Council of Australia (NHMRC) (APP1132975) . The contents of the published material are solely the responsibility of the individual authors and do not reflect the views of NHMRC. A. Devine and D.J. Price's research are supported by DFAT. C.R. Walker's research is supported by the Andrew Sisson support package.