Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy — A focus on energy expenditure

A Stefanidis; CMC Lee; E Greaves; MK Montgomery; M Arnold; S Newn; AJ Budin; MB Lemus; CJ Foldi; PR Burton; WA Brown; TA Lutz; MJ Watt; BJ Oldfield

Journal article

Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy — A focus on energy expenditure

A Stefanidis, CMC Lee, E Greaves, MK Montgomery, M Arnold, S Newn, AJ Budin, MB Lemus, CJ Foldi, PR Burton, WA Brown, TA Lutz, MJ Watt, BJ Oldfield

Molecular Metabolism | Published : 2023

DOI: 10.1016/j.molmet.2023.101739

Open access

Abstract

Objective: Bariatric surgery remains the only effective and durable treatment option for morbid obesity. Vertical Sleeve Gastrectomy (VSG) is currently the most widely performed of these surgeries primarily because of its proven efficacy in generating rapid onset weight loss, improved glucose regulation and reduced mortality compared with other invasive procedures. VSG is associated with reduced appetite, however, the relative importance of energy expenditure to VSG-induced weight loss and changes in glucose regulation, particularly that in brown adipose tissue (BAT), remains unclear. The aim of this study was to investigate the role of BAT thermogenesis in the efficacy of VSG in a rodent mo..

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University of Melbourne Researchers

Magda Montgomery Author

Matt Watt Author

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (APP1145142) received by B.J.O., W.A.B., and P.B.B. and the Australian Diabetes Research Foundation (APP Y18G-STEA) received by A.S. The authors acknowledge the technical assistance of Monash Histology Platform, Department of Anatomy and Developmental Biology, Monash University.