Poly(ethylene glycol) Cross-Linked Antibody Nanoparticles for Tunable Biointeractions

Yingjie Hu; Christina Cortez-Jugo; Yi Ju; Tian Zheng; Jiajing Zhou; Zhixing Lin; Robert De Rose; Christoph E Hagemeyer; Karen Alt; Frank Caruso

Journal article

Poly(ethylene glycol) Cross-Linked Antibody Nanoparticles for Tunable Biointeractions

Yingjie Hu, Christina Cortez-Jugo, Yi Ju, Tian Zheng, Jiajing Zhou, Zhixing Lin, Robert De Rose, Christoph E Hagemeyer, Karen Alt, Frank Caruso

Chemistry of Materials | American Chemical Society (ACS) | Published : 2023

DOI: 10.1021/acs.chemmater.3c00323

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Abstract

Liver accumulation of nanoparticles is a major challenge in nanoparticle-mediated delivery as it can reduce the delivery of the nanoparticles to their intended site and lead to liver damage and toxicity. Recent studies have shown that particle engineering, e.g., nanoparticle composition, can influence liver uptake and allow homing of nanoparticles to specific organs or tissues. Herein, we investigated the role of nanoparticle cross-linking on liver uptake. We developed a series of antibody nanoparticles (AbNPs) using various poly(ethylene glycol) (PEG) molecule (e.g., different arm numbers and arm lengths) cross-linkers. Specifically, AbNPs based on Herceptin were engineered with PEG cross-l..

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University of Melbourne Researchers

Christina Cortez-Jugo Author

Yi David Ju Author

Tian Zheng Author

Zhixing Lin Author

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Awarded by University of Melbourne

Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). F.C. acknowledges the award of a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (GNT1135806). C.E.H. and F.C. acknowledge the award of a NHMRC Project Grant (GNT1138361) that also supported this work. F.C. and Y.J. acknowledge the award of an Australian Research Council Discovery Project (DP210103114) scheme that also supported this work. Y.J. acknowledges the award of an RMIT Vice Chancellor's Postdoctoral Fellowship. K.A. acknowledges the award of an NHMRC Career Development Fellowship (GNT1140465). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). We thank Dr. Andrew Mitchell (MCFP) for his contribution in obtaining animal ethics approval.