To speak may draw on epigenetic writing and reading: Unravelling the complexity of speech and language outcomes across chromatin-related neurodevelopmental disorders

M St John; T Tripathi; AT Morgan; DJ Amor

Journal article

To speak may draw on epigenetic writing and reading: Unravelling the complexity of speech and language outcomes across chromatin-related neurodevelopmental disorders

M St John, T Tripathi, AT Morgan, DJ Amor

Neuroscience and Biobehavioral Reviews | Published : 2023

DOI: 10.1016/j.neubiorev.2023.105293

Abstract

Speech and language development are complex neurodevelopmental processes that are incompletely understood, yet current evidence suggests that speech and language disorders are prominent in those with disorders of chromatin regulation. This review aimed to unravel what is known about speech and language outcomes for individuals with chromatin-related neurodevelopmental disorders. A systematic literature search following PRISMA guidelines was conducted on 70 chromatin genes, to identify reports of speech/language outcomes across studies, including clinical reports, formal subjective measures, and standardised/objective measures. 3932 studies were identified and screened and 112 were systematic..

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University of Melbourne Researchers

Tanya Tripathi Author

Angela Morgan Author

David Amor Author

Miya St John Author

Related Projects (1)

CENTRE FOR RESEARCH EXCELLENCE IN SPEECH AND LANGUAGE NEUROBIOLOGY (CRE-SLANG)

Half a million Australian children have a speech/language disorder, tripling their changes of poor academic outcomes, limited employment opt..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was supported by funding from the National Health and Medical Research Council awarded to ATM & DJA (Grant/Award Number: #1116976) , the Lorenzo and Pamela Galli Medical Research Trust (DJA) and the KAT6 Foundation (TT) .