Journal article
Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis
AW Debowski, NM Bzdyl, DR Thomas, NE Scott, CH Jenkins, J Iwasaki, EA Kibble, CA Khoo, NJ Scheuplein, PM Seibel, T Lohr, G Metters, CS Bond, IH Norville, KA Stubbs, NJ Harmer, U Holzgrabe, HJ Newton, M Sarkar-Tyson
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2023
Abstract
Coxiella burnetii is a Gram-negative intracellular pathogen that causes the debilitating disease Q fever, which affects both animals and humans. The only available human vaccine, Q-Vax, is effective but has a high risk of severe adverse reactions, limiting its use as a countermeasure to contain outbreaks. Therefore, it is essential to identify new drug targets to treat this infection. Macrophage infectivity potentiator (Mip) proteins catalyse the folding of proline-containing proteins through their peptidyl prolyl cis-trans isomerase (PPIase) activity and have been shown to play an important role in the virulence of several pathogenic bacteria. To date the role of the Mip protein in C. burne..
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Grants
Awarded by NHMRC
Awarded by Dstl
Awarded by North Atlantic Treaty Organization (NATO), Brussels, Belgium
Awarded by German Research Foundation (DFG, Bonn, Germany)
Funding Acknowledgements
Funding for HJN's research team is supported by NHMRC Idea's grant 2010841. This work was supported by Dstl contract DSTLX-1000051512 to NJH. IHN, CHJ and GM were funded by the UK Ministry of Defence. This work & nbsp;was supported by the North Atlantic Treaty Organization (NATO), Brussels, Belgium grant SPS 984835, and the German Research Foundation (DFG, Bonn, Germany; grant SFB 630) for the development of Mip inhibitors against L. pneumophila and B. pseudomallei, respectively, and The Federal Ministry of Education and Research for the development of Mip inhibitors against T. cruzi and B. pseudomallei, given to UH. This paper includes research that was supported by DMTC Limited (Australia) to MST, AWD, NMB, JI and EAK. The authors have prepared this paper in accordance with the intellectual property rights granted to partners from the original DMTC project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.