Journal article
Apoptosis of Multi-Drug Resistant Candida Species on Microstructured Titanium Surfaces
Phuc HH Le, Denver P Linklater, Arturo Aburto-Medina, Shuai Nie, Nicholas AA Williamson, Russell JJ Crawford, Shane Maclaughlin, Elena PP Ivanova
Advanced Materials Interfaces | Wiley Open Access | Published : 2023
Abstract
The proportion of hospital-acquired medical device infections caused by pathogenic, multi-drug resistant Candida species occurs in up to 10% of implantations. In this study, a unique antifungal micro-pillared titanium surface pattern is developed, which demonstrates both fungicidal and fungistatic activity, persistently deterring biofilm formation by Candida albicans and multi-drug resistant Candida auris fungi for up to 7 days. The Ti micropillars of 3.5 µm height are fabricated using maskless inductively coupled plasma reactive ion etching. The micro-textured surface consistently kills ≈50% of Candida spp. irreversibly attached cells and prevent the proliferation of the remaining cells by ..
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Awarded by Australian Research Council through the ARC Research Hub for Australian Steel Manufacturing under the Industrial Transformation Research Hubs scheme
Funding Acknowledgements
& nbsp;The authors would like to thank the ARC Research Hub for Australian Steel Manufacturing for funding this research. The authors would like to thank the Microscopy and Microanalysis Facility (RMMF) at RMIT University and the ARC Training Centre for Surface Engineering for Advanced Materials (SEAM) for the use of their facilities. This work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). The authors would like to thank the Melbourne Mass Spectrometry and Proteomics Facility at The Bio21 Molecular Science and Biotechnology Institute at The University of Melbourne. Graphical abstract was created with BioRender.com. This study was supported by the Australian Research Council through the ARC Research Hub for Australian Steel Manufacturing under the Industrial Transformation Research Hubs scheme (Project ID: IH130100017). Open access publishing facilitated by RMIT University, as part of the Wiley - RMIT University agreement via the Council of Australian University Librarians.