Journal article
Developing the supraparticle technology for round window-mediated drug administration into the cochlea
N Gunewardene, Y Ma, P Lam, S Wagstaff, C Cortez-Jugo, Y Hu, F Caruso, RT Richardson, AK Wise
Journal of Controlled Release | Published : 2023
Abstract
The semi-permeable round window membrane (RWM) is the gateway to the cochlea. Although the RWM is considered a minimally invasive and clinically accepted route for localised drug delivery to the cochlea, overcoming this barrier is challenging, hindering development of effective therapies for hearing loss. Neurotrophin 3 (NT3) is an emerging treatment option for hearing loss, but its therapeutic effect relies on sustained delivery across the RWM into the cochlea. Silica supraparticles (SPs) are drug delivery carriers capable of providing long-term NT3 delivery, when injected directly into the guinea pig cochlea. However, for clinical translation, a RWM delivery approach is desirable. Here, we..
View full abstractGrants
Awarded by U.S. Department of Defense
Funding Acknowledgements
This work was funded with support from the Department of Defence USA, Hearing Restoration Research Program, Translational Research Award W81XWH1810276, The Passe and Williams Foundation, the Bulley Foundation and the Australian National Health and Medical Research Council (GNT 1142910) . F.C. acknowledges the award of a National Health and Medical Research Council Leadership Fellowship (GNT2016732) . The Bionics Institute acknowledges the support it receives from the Victorian Government, Australia, through its Operational Infrastructure Support Program. The authors would like to thank Trung Nguyen, Donna Tuari, James Firth, Sayward Barone, Brianna Flynn, Alex Thompson, Ella Trang and Caitlin Singleton from the Bionics Institute, Melbourne, Australia, for technical assistance, Patricia WM Ho from St Vincent's Institute, Melbourne, Australia for the use of the gamma counter and David Casley from ProSearch International, Melbourne, Australia, for technical assistance with protein radiolabelling. Zhixing Lin from University of Melbourne, Australia, for technical assistance with SEM-EDX.