Mucosal antibody responses following Vaxzevria vaccination

KJ Selva; P Ramanathan; ER Haycroft; CW Tan; LF Wang; LE Downie; SK Davis; RA Purcell; HE Kent; JA Juno; AK Wheatley; MP Davenport; SJ Kent; AW Chung

Journal article

Mucosal antibody responses following Vaxzevria vaccination

KJ Selva, P Ramanathan, ER Haycroft, CW Tan, LF Wang, LE Downie, SK Davis, RA Purcell, HE Kent, JA Juno, AK Wheatley, MP Davenport, SJ Kent, AW Chung

Immunology and Cell Biology | Published : 2023

DOI: 10.1111/imcb.12685

Abstract

Mucosal antibodies play a key role in protection against breakthrough COVID-19 infections and emerging viral variants. Intramuscular adenovirus-based vaccination (Vaxzevria) only weakly induces nasal IgG and IgA responses, unless vaccinees have been previously infected. However, little is known about how Vaxzevria vaccination impacts the ability of mucosal antibodies to induce Fc responses, particularly against SARS-CoV-2 variants of concern (VoCs). Here, we profiled paired mucosal (saliva, tears) and plasma antibodies from COVID-19 vaccinated only vaccinees (uninfected, vaccinated) and COVID-19 recovered vaccinees (COVID-19 recovered, vaccinated) who both received Vaxzevria vaccines. SARS-C..

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University of Melbourne Researchers

Kevin John Selva Author

Pradhipa Ramanathan Author

Laura Downie Author

Jennifer Juno Author

Related Projects (1)

Defining immune responses in COVID-19 to understand susceptibility and target treatments

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We express our gratitude towards the participants for their generous time and gracious provision of samples. We thank T~Amarasena, R Esterbauer, K Wragg, P Konstandopoulos, G~Gare, K Field, H Kelly and A Kelly (University of Melbourne) for their outstanding technical support. We thank Dale Godfrey, Nicholas Gherardin and Samuel Redmond (University of Melbourne) for generously sharing their recombinant biotinylated-ACE-2 protein. We thank Bruce D Wines and P Mark Hogarth (Burnet Institute) for generously sharing their soluble Fc Receptor dimers. This study was supported by the Medical Research Future Fund (MRFF) GNT #2005544 to JAJ, SJK, AWC and GNT #2016062 to JAJ, MPD, SJK, AWC. JAJ, MPD, SJK and AWC are supported by NHMRC Investigator grants. The Duke-NUS team is supported by grants from NMRC Singapore (STPRG-FY19-001, COVID19RF-003 and OFLCG19May-0034). Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians.