Journal article
Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness
Julian Wenzel, Luzie Badde, Shalaila S Haas, Carolina Bonivento, Tamsyn E van Rheenen, Linda A Antonucci, Anne Ruef, Nora Penzel, Marlene Rosen, Theresa Lichtenstein, Paris Alexandros Lalousis, Marco Paolini, Alexandra Stainton, Udo Dannlowski, Georg Romer, Paolo Brambilla, Stephen J Wood, Rachel Upthegrove, Stefan Borgwardt, Eva Meisenzahl Show all
Neuropsychopharmacology | Springer Nature [academic journals on nature.com] | Published : 2024
Abstract
Cognitively impaired and spared patient subgroups were identified in psychosis and depression, and in clinical high-risk for psychosis (CHR). Studies suggest differences in underlying brain structural and functional characteristics. It is unclear whether cognitive subgroups are transdiagnostic phenomena in early stages of psychotic and affective disorder which can be validated on the neural level. Patients with recent-onset psychosis (ROP; N = 140; female = 54), recent-onset depression (ROD; N = 130; female = 73), CHR (N = 128; female = 61) and healthy controls (HC; N = 270; female = 165) were recruited through the multi-site study PRONIA. The transdiagnostic sample and individual study grou..
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Funding Acknowledgements
Recruitment, follow-up of the study participants/implementation of examination protocols/information technological infrastructure/data quality control: PRONIA consortium.