Vaccine-induced inflammation and inflammatory monocytes promote CD4 T cell-dependent immunity against murine salmonellosis

Nancy Wang; Timothy A SCOTT; Andreas KUPZ; Meghanashree M Shreenivas; Newton G Peres; Dianna M Hocking; Chenying YANG; Leila Jebeli; Lynette Beattie; Joanna R Groom; Thomas P Pierce; Linda M Wakim; Sammy Bedoui; Richard A Strugnell

Journal article

Vaccine-induced inflammation and inflammatory monocytes promote CD4 T cell-dependent immunity against murine salmonellosis

Nancy Wang, Timothy A SCOTT, Andreas KUPZ, Meghanashree M Shreenivas, Newton G Peres, Dianna M Hocking, Chenying YANG, Leila Jebeli, Lynette Beattie, Joanna R Groom, Thomas P Pierce, Linda M Wakim, Sammy Bedoui, Richard A Strugnell

PLoS Pathogens | Public Library of Science (PLoS) | Published : 2023

DOI: 10.1371/journal.ppat.1011666

Abstract

Prior infection can generate protective immunity against subsequent infection, although the efficacy of such immunity can vary considerably. Live-attenuated vaccines (LAVs) are one of the most effective methods for mimicking this natural process, and analysis of their efficacy has proven instrumental in the identification of protective immune mechanisms. Here, we address the question of what makes a LAV efficacious by characterising immune responses to a LAV, termed TAS2010, which is highly protective (80–90%) against lethal murine salmonellosis, in comparison with a moderately protective (40–50%) LAV, BRD509. Mice vaccinated with TAS2010 developed immunity systemically and were protected ag..

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University of Melbourne Researchers

Nancy Wang Author

Lynette Beattie Author

Joanna Groom Author

Linda Wakim Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Australian Research Council (ARC)

Awarded by ARC

Awarded by NHMRC

Awarded by Australian Research Council

Funding Acknowledgements

& nbsp;This study was supported by National Health and Medical Research Council (NHMRC) Program Grant 1092262 awarded to R.A.S., and Australian Research Council (ARC) Discovery Project DP200103110 awarded to N.W. and R.A.S. N.G.P., C.Y. and L.J. were supported by an Australian Postgraduate Award (APA) during the study period. For their salary support and their contribution to the study, A.K. (GNT2008715), L.B. (GNT2002682), J.R.G. (GNT2007812), L.M.W. (GNT2007734) and S.B. (GNT2008408, GNT1159658) were supported by NHMRC. S.B. was also supported by ARC Discovery Project DP210101806.