Assessment of mineral metabolism in Chronic Kidney Disease – Mineral and Bone Disorder (CKD-MBD)

Abstract

Patients with chronic kidney disease (CKD) experience significantly poorer outcomes compared to the general population, including greater all-cause and cardiovascular-related mortality. Increased morbidity and mortality is partly attributable to the propensity for patients with CKD to be older and have an elevated burden of co-morbidities and cardiovascular risk factors. However, it is also clear that additional pathological processes specific to CKD play a role. Decline in kidney function is paralleled by progressive abnormalities in mineral and bone metabolism. This multi-system process is collectively referred to as Chronic Kidney Disease – Mineral and Bone Disorder (CKD-MBD), and is almo..