Journal article
Engineering Metal-Phenolic Network Nanoparticles via Microfluidics
J Chen, S Spoljaric, A Calatayud-Sanchez, Y Alvarez-Braña, F Caruso
ACS Applied Materials and Interfaces | Published : 2023
Abstract
Microfluidics opens new avenues for materials engineering, as it enables scalable synthesis and provides highly controllable environments for reactions. Herein, we leverage microfluidics to engineer the properties of (bioactive) metal-phenolic network nanoparticles (MPN NPs), an emerging and highly modular nanoparticle platform for the incorporation and delivery of bioactive cargo. By varying the microfluidics operating parameters (flow rate ratio, total flow rate, temperature) and NP composition, we assemble MPN NPs, which consist of poly(ethylene glycol), biomacromolecules, metal ions, and polyphenols. Compared to MPN NPs prepared via bulk assembly, the microfluidics-assembled MPN NPs poss..
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Awarded by University of Melbourne
Funding Acknowledgements
F.C. acknowledgesthe award of a National Health and MedicalResearch Council (NHMRC) Leadership Fellowship (GNT2016732). Thiswork was performed in part at the Materials Characterisation and FabricationPlatform (MCFP) and Melbourne Advanced Microscopy Facility at TheUniversity of Melbourne, and the Victorian Node of the AustralianNational Fabrication Facility (ANFF). TEM analyses were conductedusing the facilities at the Biosciences Microscopy Unit, School ofBioscience, The University of Melbourne. A.C.S. and Y.A.B. acknowledgefunding from the European Union's Horizon 2020 research andinnovation programme under grant agreement H2020-MSCA-RISE-778001and the Basque Government under Grupos Consolidados (grant no. IT1633-22).The authors acknowledge Dr. Christina Cortez-Jugo and Dr. ZhixingLin for helpful discussions, and Yuang Gu for assistance with theSDS-PAGE analysis.