Cooperative assemblies featuring hydrogen bonding and C-H...π interactions in 2-(methanesulfonamido)benzohydrazide derivatives: Experimental, computational and biochemical assessment

Abstract

The significant involvement of noncovalent interactions in catalyst design and synthesis of materials provides a fundamental impetus to explore various synthons that produce complex frameworks. Therefore, in the present work, cooperative assemblies of two methanesulfonamide containing benzohydrazide derivatives (6 and 7) were designed and analyzed. These compounds were synthesized through a straightforward approach using hydrazide 3 and 4-methyl-2-acetylthiophene (4) and 4-methoxyacetophenone (5) in refluxing ethanol. Both compounds were characterized by FTIR, NMR, LCMS and X-ray crystallography. Noncovalent interactions such as Csingle bondH…π interactions and hydrogen bonding played a cruc..