Journal article
Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis
TJ Lupancu, KMC Lee, M Eivazitork, C Hor, AJ Fleetwood, AD Cook, M Olshansky, SJ Turner, R de Steiger, K Lim, JA Hamilton, AA Achuthan
Iscience | Published : 2023
Abstract
Glucocorticoids (GCs) are potent anti-inflammatory agents and are broadly used in treating rheumatoid arthritis (RA) patients, albeit with adverse side effects associated with long-term usage. The negative consequences of GC therapy provide an impetus for research into gaining insights into the molecular mechanisms of GC action. We have previously reported that granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced CCL17 has a non-redundant role in inflammatory arthritis. Here, we provide molecular evidence that GCs can suppress GM-CSF-mediated upregulation of IRF4 and CCL17 expression via downregulating JMJD3 expression and activity. In mouse models of inflammatory arthritis, GC ..
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Awarded by Australian Research Council
Funding Acknowledgements
The project was funded by grants to AAA from the National Health and Medical Research Council (NHMRC) of Australia (1159901) and the University of Melbourne (UoM) Research Grant Support Scheme. TJL was supported by a Graduate Research Trust (Ronald John Gleghorn Bursary) Scholarship from the UoM. SJT was supported by grants (5671222 and 1003131) from the NHMRC and an Australian Research Council Future Fellowship. We thank Dr. Julia E. Smith (Immunology Research Unit, GlaxoSmithKline, UK) for her input into some of the original discussions for this work.