Journal article
Revised nucleic acid test window periods: Applications and limitations in organ donation practice
Martin Dutch, Anthea Cheng, Philip Kiely, Clive Seed
Transplant Infectious Disease | Wiley | Published : 2024
DOI: 10.1111/tid.14180
Open access
Abstract
Background Nucleic acid test window periods for HIV, HCV, and HBV facilitate estimation of the residual risk of unexpected disease transmission and assist clinicians in determining the timeframe in which a recently acquired infection is at risk of nondetection. Objectives Firstly, to provide revised estimates of the NAT window periods based on a currently used triplex NAT assay. Secondly, to examine their validity in organ donation and transplantation practice. Method Estimates were based on the Procleix Ultrio Elite Assay (Grifols Diagnostic Solutions Inc. California, USA). The manufacturer's X50 and X95 limits of detection (LOD) were utilised. Viral doubling times of 0.85, 0.45, and 2.56..
View full abstractGrants
Funding Acknowledgements
The authors would like to thank the Australian Organ and Tissue Authority & apos;s Vigilance and Surveillance Expert Advisory Committee for verifying and clarifying details surrounding the Australian unexpected donor-derived HCV transmission case. Australian Governments fund Australian Red Cross Lifeblood for the provision of blood, blood products, and services to the Australian community.r Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians.