Journal article
Clinical outcomes of deep brain stimulation for obsessive-compulsive disorder: Insight as a predictor of symptom changes
Nicola Acevedo, Susan Rossell, David Castle, Clare Groves, Mark Cook, Peter Mcneill, James Olver, Denny Meyer, Thushara Perera, Peter Bosanac
Psychiatry and Clinical Neurosciences | Wiley | Published : 2024
DOI: 10.1111/pcn.13619
Open access
Abstract
Aim Deep brain stimulation (DBS) is a safe and effective treatment option for people with refractory obsessive-compulsive disorder (OCD). Yet our understanding of predictors of response and prognostic factors remains rudimentary, and long-term comprehensive follow-ups are lacking. We aim to investigate the efficacy of DBS therapy for OCD patients, and predictors of clinical response. Methods Eight OCD participants underwent DBS stimulation of the nucleus accumbens (NAc) in an open-label longitudinal trial, duration of follow-up varied between 9 months and 7 years. Post-operative care involved comprehensive fine tuning of stimulation parameters and adjunct multidisciplinary therapy. Results..
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Awarded by Australian Government Research Training Program Scholarship
Funding Acknowledgements
The authors would like to thank the participants who kindly contributed their time to the project. Also, Simon Vogrin, who provided technical support in the acquisition and data management of the neuroimaging scans. The authors disclose receipt of the following financial support for the research, authorship and/or publication of this article. NA holds an Australian Government Research Training Program Scholarship. SLR holds a Senior National Health and Medical Research Council (NHMRC) Fellowship (GNT1154651). PB holds a perpetual IMPACT philanthropy grant (IPAP2017/1439). The authors declare no conflict of interest. Open access publishing facilitated by Swinburne University of Technology, as part of the Wiley - Swinburne University of Technology agreement via the Council of Australian University Librarians.