Journal article
Protein target highlights in CASP15: Analysis of models by structure providers
LT Alexander, J Durairaj, A Kryshtafovych, LA Abriata, Y Bayo, G Bhabha, C Breyton, SG Caulton, J Chen, S Degroux, DC Ekiert, BS Erlandsen, PL Freddolino, D Gilzer, C Greening, JM Grimes, R Grinter, M Gurusaran, MD Hartmann, CJ Hitchman Show all
Proteins Structure Function and Bioinformatics | Published : 2023
DOI: 10.1002/prot.26545
Abstract
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integr..
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Awarded by New York University
Funding Acknowledgements
Australian Research Council; Cancer Prevention and Research Institute of Texas; Department of Biological and Agroalimentary Sciences of the Italian National Research Council; Fundamental Research Funds for theCentral Universities; Jane Coffin Childs Memorial Fund for Medical Research; LISCB Wellcome Trust ISSF; Max-Planck-Gesellschaft; National Health and Medical Research Council; National Institutes of Health; National Natural Science Foundation of China; National Science Foundation; NYU Langone Health Antimicrobial-resistantPathogen Program; Pew Charitable Trusts; Schmidt Science Fellows; Schweizerischer Nationalfonds zur Foerderung der Wissenschaftlichen Forschung; & nbsp;Welch Foundation; Wellcome Trust; Wellcome Trust Seed Award in Science